Thyroid therapy reduced the complications of hemorrhagic shock in dogs

· Shigematsu H, Shatney CH. The effect of triiodothyronine (T3) and reverse triiodothyronine (rT3) on canine hemorrhagic shock. Nippon Geka Gakkai Zasshi. 1988 Oct;89(10):1587-93.

· UK Guidelines for the Use of Thyroid Function Tests (July 2006) http://www.british-thyroid-association.org/info-for-patients/Docs/TFT_guideline_final_version_July_2006.pdf

· Amerling R, Winchester JF, Ronco C, “Guidelines have done more harm than good,”Blood Purification 2008;26;73-76.

· Guirguis-Blake J, Calonge N, Miller T, Siu A, Teutsch S, Whitlock E., “Current processes of the U.S. Preventive Services Task Force: refining evidence-based recommendation development”. Ann. Intern. Med 2007; 147(2):117–22.

· Barton MB, Miller T, Wolff T, et al. “How to read the new recommendation statement: methods update from the U.S. Preventive Services Task Force,” Ann. Intern. Med 2007;147(2):123–7.

· CEBM > EBM Tools > Finding the Evidence > Levels of Evidence http://www.cebm.net/levels_of_evidence.asp#levels.

· Atkins D, Best D, Briss PA, et al. (2004). “Grading quality of evidence and strength of recommendations,” BMJ 2004;328 (7454):1490.

· Tricoci P, Allen JM, Kramer KM, et al. Scientific evidnce underlying the ACC/AHA clincal practice guidelines. JAMA 2009;301(8):831-841.

· British Thyroid Foundation and NHS Choices: http://www.talkhealthpartnership.com/forum/viewforum.php?f=123

· Pritchard EK, “The Linguistic Etiologies of Thyroxine-Resistant Hypothyroidism,” Thyroid Science www.thyroidscience.com – click on “debate.”

· Gossel, TA, Endocrinology Continuing Education accredited by the Accreditation Council for Continuing Medical Education (ACCME), 2005

· Baskin, HJ, MD, Medical Guidelines for Clinical Practice for the Evaluation and Treatment of Hyperthyroidism and Hypothyroidism, Am Assoc Clin Endocrinol, 2002, Rev 2006

· Levy EG, Ridgway EC, Wartofsky L, Algorithms for Diagnosis and Management of Thyroid Disorders, www.thyroidtoday.com 2004.

· The American Thyroid Association provides links to several hypothyroidism related guidelines: “Use of Laboratory Tests in Thyroid Disorders,” “Treatment Guidelines for

· Patients with Hyperthyroidism and Hypothyroidism,” and “Guidelines for Detection of Thyroid Dysfunction.”

· Levy EG, Hypothyroidism Treatment Failure: Differential Diagnosis, www.thyroidtoday.com 2004.

· Vanderpump MPJ, Ahlquist JAO, Franklyn JA, et al., Consensus Statement for Good Practice and Audit Measures in the Management of Hypothyroidism and Hyperthyroidism, BMJ, August 1996

· Garber JR, Hennessey JV, Lieberman JA, Morris CM, Talbert RI, Managing the Challenges of Hypothyroidism, Supplement to J of Fam Pract, 2006, www.jponline.com

· Kaplan MM, Clinical Perspectives in the Diagnosis of Thyroid Disease, Clin Chem, 1999, 45:8(B) 1377-1383

· Henryk Zulewski, Beat Müller, Pascale Exer, André R. Miserez and Jean-Jacques Staub:Estimation of Tissue Hypothyroidism by a New Clinical Score: Evaluation of Patients with Various Grades of Hypothyroidism and Controls: The Journal of Clinical Endocrinology & Metabolism March 1, 1997 vol. 82 no. 3 771-776

· Tolulope O Olateju and Mark P J Vanderpump. Thyroid hormone resistance. Ann Clin Biochem 1 November 2006 vol. 43 no. 6 431-440

· The Royal College of Physicians Clinical Guidelines: http://www.rcplondon.ac.uk/resources/clinical/guidelines

· Introduction to Tort: 2/14/2008 http://www.oup.com/uk/orc/bin/9780199292240/strong_ch01.pdf

· Kirk E, Kvorning SA, Acta Med. Scandinav., Suppl. 184. pp 3-83. 1947

· Means JH, Lectures on Thyroid, Cambridge, Harvard University Press, pgs 48-49, 1954

· Baisier, WV, Hertoghe, J., Beekhaut, W., Thyroid Insufficiency? Is Thyroxine the Only Valuable Drug?, Journal of Nutritional and Environmental Medicine, Vol 11, No. 3, September 2001, pages 159-166

· Gross J, Pitt-Rivers R, 3:5:3'-Triiodothyronine Physilogical Activity, Biochem, Vol 53, pgs 652-57, 1953

· Refetoff S, Weiss RE, Usala SJ, The Syndromes of Resistance to Thyroid Hormone, Endocr Rev, 1993, 14(3):348-399

· Braverman LE, Ingbar SH, Keinwem S, Conversion of Thyroxine (T4) to Triiodothyronine (T3) in Athyreotic Human Subjects, The J Clin Invest, 1970, 49

· Saravanan P, Chau F, Roberts N, Vedhara K, Greenwood R, Dayan CM, 2002, Psychological Well-Being in Patients on "Adequate" Doses of L-Thyroxine Results of a Large, Controlled Community-Based Questionnaire Study, Clinical Endocrinology, 2002, 57: 577-585

· Turner S. Register of Counterexamples to T4 monotherapy. http://www.tpa-uk.org.uk/register_of_counterexamples.php

· John Saunders. The practice of clinical medicine as an art and as a science. Med Humanities 2000;26:18-22 doi:10.1136/mh.26.1.18

· Wilson James L. Adrenal Fatigue, The 21st Century Stress Syndrome. Smart Publications. ISBN 1-890572-15-2

· General Medical Council. Good Medical Practice: Providing good clinical care. http://www.gmc-uk.org/guidance/good_medical_practice/good_clinical_care_index.asp

· Lowe, J.C.: Thyroid hormone replacement therapies: ineffective and harmful for many hypothyroid patients. Thyroid Science, 1(1):C1-21, 2006. http://www.thyroidscience.com/Criticism/lowe.dec.2006/t4%2 0vs%20t4t3%20studies.htm

· Bunevicius, R., Kazanavicius, G., Zalinkevicius, R., et al.: Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N. Engl. J. Med., 340:424-429, 1999.

· Escobar-Morreale, H.F., Botella-Carretero, J.I., Gómez-Bueno, M., et al.: Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. Ann. Intern. Med., 142(6): 412-424, 2005.1

· Appelhof, B.C., Fliers, E., Wekking, E.M., et al.: Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine Monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial. J. Clin. Endocrinol. Metab., 90(5):2666-2674, 2005.

· Walsh, J.P., Shiels, L., Mun Lim, E.E., et al.: Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism. J. Clin. Endocrinol. Metab., 88(10):4543-4550, 2003.

· Saravanan, P., Chau, W.F., Roberts, N., et al.: Psychological well-being in patients on ‘adequate’ doses of L-thyroxine: results of a large, controlled community- based questionnaire study. Clin. Endocrinol.(Oxf.), 57(5):577-585, 2002.

· Sawka, A.M., Gerstein, H.C., Marriott, M.J., et al.: Does a combination regimen of thyroxine (T4) and 3,5,3’-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial. J. Clin. Endocrinol. Metab., 88(10):4551-4555, 2003.

· Walsh, J.P.: Dissatisfaction with thyroxine therapy: could the patients be right? Curr. Opin. Pharmacol., 2:717–722, 2002.

· Clyde, P.W., Harari, A.E., Getka, E.J., and Shakir, K.M.M.: Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial. J.A.M.A., 290:2952-2958, 2003.

· Cassio, A., Cacciari, E., Cicgnani, A., et al.: Treatment of congenital hypothyroidism: thyroxine alone or thyroxine plus triiodothyronine? Pediatrics, 111(5): 1055-1060, 2003.

· Mangieri, C.N. and Hund, M.H.: Potency of United States Pharmacopeia desiccated thyroid tablets as determined by the antigoitrogenic assay in rats. J. Clin. Endocrinol. Metab., 30:102-104, 1970

· Saravanan, P., Simmons, D.J., Greenwood, R., et al.: Partial substitution of thyroxine (T4) with tri-iodothy-ronine in patients on T4 replacement therapy: results of a large community-based randomized controlled trial. J. Clin. Endocrinol. Metab., 90(2):805-812, 2005.

· Grozinsky-Glasberg, S., Fraser, A., Nahshoni, E., et al.: Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothy

· Lowe, J.C.: Stability, effectiveness, and safety of desiccated thyroid.... Thyroid Science 4(3):C1-12, 2009 11 roidism: meta-analysis of randomized controlled trials. J. Clin. Endocrinol. Metab., 91:2592-2599, 2006.

· Cobb, W.E. and Jackson, I.M.: Drug therapy reviews: management of hypothyroidism.Am. J. Hosp. Pharm., 35(1):51-58, 1978.

· Bastemir, M., Akin, F., Alkis, E., et al.: Obesity is associated with increased serum TSH level, independent of thyroid function. Swiss. Med. Wkly., 137(29-30): 431-434, 2007.

· Bunevicius, R. and Prange, A.J.: Mental improvement after replacement therapy with thyroxine plus triiodothyronine: relationship to cause of hypothyroidism. Int. J. Neuropsychopharmacol., 3(2):167-174, 2000.

· Bunevicius, R., Jakubonien, N., Jurkevicius, R., et al.: Thyroxine vs thyroxine plus triiodothyronine in treatment of hypothyroidism after thyroidectomy for Graves’ disease. Endocrine, 18(2):129-133, 2002

· The SIGN Guide to the AGREE guideline appraisal instrument.. http://www.sign.ac.uk/methodology/agreeguide/index.html.

· Royal College of Physicians. 4 February 2009: ‘Patients need UK medicines strategy’ http://www.politics.co.uk/opinion-formers/royal-college-of-physicians/article/patients-need-uk-medicines-strategy-says-rcp

· Armour Thyroid (USP) and combined thyroxine/ tri-iodothyronine as Thyroid Hormone Replacement. A Statement from the British Thyroid Association Executive Committee November 2007- http://www.british-thyroid-association.org/Guidelines/Docs/Armour_nov_07.pdf

· Turner S, The Thyroid Patient Advocacy (TPA Response to the British Thyroid Association’s (BTA) Statement on the Use of Combination Thyroxine/Triiodothyronine (Liothyronine) Therapy, Thyroid Patient Advocacy www.tpa-uk.org.uk/resp_bta_t4t3.pdf

· Thyroid Science: Letters Related to Dr. Lowe's Rebuttal to the British Thyroid Association http://www.thyroidscience.com/letters/letters.bta.htm

· Cooper, D.S.: Combined T4 and T3 therapy—back to the drawing board. J.A.M.A., 290:3002-3004, 2003.

· Gorowski, T., Pucilowska, J., and Wernic, K.: Comparative effects of desiccated thyroid gland and sodium salt of L-thyroxine in the treatment of hypothyroidism. Pol. Tyg. Lek., 44(32-33):768-770, 1989.

· Krenning, E.P., Docter, R., Visser, T.J., et al.: Replacement therapy with L-thyroxine: serum thyroid hormone and thyrotropin levels in hypothyroid patients changing from desiccated thyroid to pure thyroxine substitution therapy. Neth. J. Med., 28(1):1-5, 1981.

· Felt, V. and Nedvidkova, J.: Comparison of treatment with L-thyroxine and a dried thyroid gland preparation in patients with hypothyroidism. Vnitr. Lek., 28 (11):1067-1073, 1982.

· Cobb, W.E. and Jackson, I.M.: Drug therapy reviews: management of hypothyroidism. Am.J. Hosp. Pharm., 35(1):51-58, 1978.

· Wartofsky, L.: Combined levotriiodothyronine and levothyroxine therapy for hypothyroidism: are we a step closer to the magic formula? Thyroid, 14(4):247-248, 2004.

· Rodriguez, T., Lavis, V.R., Meininger, J.C., et al.: Substitution of liothyronine at a 1:5 ratio for a portion of levothyroxine: effect on fatigue, symptoms of depression, and working memory versus treatment with levothyroxine alone. Endocr. Pract., 11:223–233,2005.

· Kosowicz, J., Horst-Sikorska, W., Lacka, K., et al. Outcome of treating hypothyroidism with thyreoideum. Pol. Tyg. Lek, 48(27-28):599-602, 1993.

· Warszawie, C.M.K.P.: Treatment of hypothyroidism with L-thyroxine. Pol. Tyg. Lek, 48(27-28):605-608, 1993.

· Singh, S.P., Feldman, E.B., and Carter, A.C.: Desiccated thyroid and levothyroxine in hypothyroidism:comparison in replacement therapy. N.Y. State J. Med., 72(9):1045-1048, 1972.

· Sawin, C.T., Hershman, J.M., Fernandez-Garcia, R., et al.: A comparison of thyroxine and desiccated thyroid in patients with primary hypothyroidism. Metabolism, 27(10):1518-1525, 1978.

· Smith, R.N., Taylor, S.A., and Massey, J.C.: Controlled clinical trial of combined triiodothyronine andthyroxine in the treatment of hypothyroidism. Brit. Med. J., 4:145-148, 1970.

· McGavack, T.H. and Reckendorf, H.K.: Therapeutic activity of desiccated thyroid substance, sodium Lthyroxine and D, L-triiodothyronine: a comparative study. Am. J. Med., 20:774-777, 1956.

· J Clin Endocrinol Metab 91:2592–2599, 2006)

· Celi FS, Zemskova M, Linderman JD, et al., The pharmacodynamic equivalence of levothyroxine and liothyronine. A randomized, double-blind, cross-over study in thyroidectomized patients., Clin Endocrinol, 2010 May; 72(5) 709-715, doi: 10.1111/j.1365-2265.2009.03700.x.

· Avantika C. Waring et.al. Thyroid Function and Mortality in Older Men: A Prospective Study. The Journal of Clinical Endocrinology & Metabolism January 11, 2012 jc.2011-2684

· Bjørn O. Åsvold, Lars J. Vatten, Kristian Midthjell and Trine Bjøro; November 2, 2011, doi: 10.1210/jc.2011-1724: The Journal of Clinical Endocrinology & Metabolism January 1, 2012 vol. 97 no. 1 93-99

· Joffe R, Blank DW, Post RM, Uhde TW. Decreased triiodothyronines
in depression: A preliminary report. BIOLOGICAL PSYCHI 1985;
20: 922-925.

· Cooke RG, Joffe RT, Levitt AJ. T3 augmentation of antidepressant
treatment in T4-replaced thyroid patients. J CLIN PSYCHI 1992;
53, 1 (Jan): 16-18.

· Gelenberg AJ. T3 + T4 = success. BIOLOGICAL THERAPIES IN PSYCHI
NEWS-LTR 1992; 15, 4 (April): 14.

· Dommisse J. T3 is at least as important as T4 in all hypothyroid patients.J Clin Psychiatry. 1993 Jul;54(7):277-9.

· Whybrow PC (1994): The therapeutic use of triiodothyronine and high dose thyroxine in psychiatric disorder. Acta Medica Austriaca 21:47-5

· CHOPRA IJ: Euthyroid sick syndrome: is it a misnomer? J Clin Endocrinol Metab 82: 329-334, 1997.

· Leslie J. De Groot. Dangerous Dogmas in Medicine: The Nonthyroidal Illness Syndrome. The Journal of Clinical Endocrinology & Metabolism January 1, 1999 vol. 84 no. 1 151-164

· Chester Ridgway et.al. The Colorado Thyroid Disease Prevalence Study. Arch Intern Med. 2000;160:526-534.

· O’Reilly DS. Thyroid function tests-time for a reassessment. BMJ. 2000;320:1332–4.

· Ferreti E et. al Evaluation of the Adequacy of Levothyroxine Replacement Therapy in Patients with Central Hypothyroidism. The Journal of Clinical Endocrinology & Metabolism March 1, 1999 vol. 84 no. 3 924-929

· Turner S. Thyroid Patient Advocacy Hypothyroid Patient Survey: http://www.tpa-uk.org.uk/tpauk_survey.pdf

· Turner S. Thyroid Patient Advocacy. Register of Counterexamples. http://www.tpa-uk.org.uk/register_of_counterexamples.php

· Po.AL, Kendall MJ.. Causality assessment of adverse effects: when is re-challenge ethically acceptable? Drug Saf.2001;24(11):793-9.

· The Royal College of Physicians “Patients need UK medicines strategy” Press Release. http://www.politics.co.uk/opinion-formers/press-releases/health/patients-need-uk-medicines-strategy-says-rcp-$1266188$365674.htm